| N-Hydroxysuccinimide Chemical Properties | |
| Melting point | 95-98 °C(lit.) |
| Boiling point | 215.33°C (rough estimate) |
| density | 1.4769 (rough estimate) |
| refractive index | 1.4080 (estimate) |
| storage temp. | 2-8°C |
| form | Liquid or Solid |
| color | Clear yellow-brown to brown |
| PH | 5-7 (50g/l, H2O, 20℃) |
| Water Solubility | SOLUBLE |
| Sensitive | Hygroscopic |
| BRN | 113913 |
| Stability: | Stable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, strong bases. Protect from moisture. |
| InChIKey | NQTADLQHYWFPDB-UHFFFAOYSA-N |
| CAS DataBase Reference | 6066-82-6(CAS DataBase Reference) |
| NIST Chemistry Reference | N-hydroxylsuccinimide(6066-82-6) |
| EPA Substance Registry System | 2,5-Pyrrolidinedione, 1-hydroxy-(6066-82-6) |
| Safety Information | |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 22-24/25-26-36 |
| WGK Germany | 3 |
| Hazard Note | Irritant |
| TSCA | Yes |
| HS Code | 29251995 |
| N-Hydroxysuccinimide Usage And Synthesis | |
| Chemical Properties | White to pale yellow |
| Uses | Reagent for preparation of active esters of amino acids. |
| Uses | Useful in the carbodiimide method for improved amidations and peptide couplings. |
| Uses | Additive used in the carbodiimide method for improved amidations and peptide couplings. |
| Purification Methods | Recrystallise the imide from EtOH/ethyl acetate [Manesis & Goodmen J Org Chem 52 5331 1987]. [Beilstein 21/9 V 498.] |
| N-Hydroxysuccinimide Preparation Products And Raw materials | |
| Raw materials | Hydroxylamine hydrochloride-->Succinic anhydride |
| Preparation Products | Enalapril-->Imidapril-->N-ACRYLOXYSUCCINIMIDE-->Arbekacin-->Aspoxicillin-->GUSPERIMUS |
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