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  • Product Name:   N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
  • Synonyms:   Ethyl 2-ethoxy-1,2-dihydro-1-quinolinecarboxylate for synthesis;ethyl N-(2-ethoxy-1,2-dihydroquinoline)carboxylate;EEDQ (1-ETHOXY-CARBONYL-2-ETHOXY-1,2;EEDQ, 99+%, (2-ETHOXY-1-ETHOXYCARBONYL-1 ,2-DIHYDROQUINOLINE);Eedq(2-Ethoxy-1-Ethoxycarbonyl-1,2-Dihydroquinoline)
  • CAS No.:   16357-59-8
  • Molecular Formula:   C14H17NO3
  • Molecular Weight :   247.29
  • Specification :   98%
  • Place of Origin:   China
  • Appearance :   
  • Document :   Download

Description of N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline



N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline Chemical Properties


Melting point  62-67 °C(lit.)


Boiling point  125-128 °C (0.1 mmHg)


density  1.1173 (rough estimate)


refractive index  1.5300 (estimate)


Fp  125-128°C/0.1mm


storage temp.  2-8°C


form  Crystalline Powder


color  White to beige


Water Solubility  insoluble


Sensitive  Moisture Sensitive


Merck  14,3518


BRN  533048


CAS DataBase Reference 16357-59-8(CAS DataBase Reference)


EPA Substance Registry System 1(2H)-Quinolinecarboxylic acid, 2-ethoxy-, ethyl ester(16357-59-8)




Safety Information


Hazard Codes  Xi,Xn


Risk Statements  38-36/37/38-20/21/22


Safety Statements  22-24/25-36/37/39-26-36


WGK Germany  3


RTECS  VB2010000


9-21


TSCA  Yes


HS Code  29334990




N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline Usage And Synthesis


Chemical Properties White to pale yellow solid


Uses Peptide condensing agent with little or no racemization. Amidation coupling reagent.


Uses In the synthesis of peptides.


Purification Methods Dissolve EEDQ ~180g in CHCl3, evaporate to dryness in a vacuum. Add dry Et2O (20mL) and a white solid separates on standing. Set aside for a few hours, collect the solid, wash it thoroughly with cold Et2O and dry it in a vacuum (~140g, m 63.5-65o). A further crop of solid (~25g) is obtained from the filtrate on standing overnight. [Fieser & Fieser Reagents for Organic Synthesis 2 191 1969, Belleau et al. J Am Chem Soc 90 823 1968 and 90 1651 1968, Beilstein 21/3 V 28.]




N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline Preparation Products And Raw materials


Raw materials Diethyl ether-->Dichloromethane-->N,N-Dimethylformamide-->Magnesium sulfate-->Potassium hydroxide -->Ethyl chloroformate-->Quinoline-->Boron trifluoride etherate


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